Story
Built in Science. Guided by Care.
Physicians Grade was created with a simple but uncommon belief: products meant to support damaged or stressed skin should be developed with the same discipline, restraint, and scrutiny found in academic research environments.
Our work did not begin with trends, marketing claims, or influencer endorsements. It began with science.
The Origin of REPYR-SC1™
REPYR-SC1™ began not as a commercial ingredient, but as a compound of scientific interest inside a leading U.S. academic medical research environment..
Over nearly two years, this phytocannabinoid-rich hemp extract was examined in collaboration with researchers operating within a university-affiliated medical research institute. Early laboratory findings prompted deeper investigation into how the compound behaved in stressed and abnormal cellular models.
What started as academic curiosity evolved into a meaningful opportunity to translate disciplined research into thoughtfully developed consumer products.
Clinically Studied. Scientifically Validated.
University-Affiliated Academic Research
Independent research conducted within a leading U.S. academic medical research environment revealed that REPYR-SC1™ demonstrated potent, dose-dependent biological activity in laboratory models relevant to squamous and basal cell behavior.
Under controlled laboratory conditions, the extract showed the ability to selectively influence abnormal cellular activity while maintaining the integrity of healthy skin cells. These findings supported further scientific evaluation of REPYR-SC1™ as a novel, biologically active skincare compound.
Presented at AACR
Findings from this academic research were published in Cancer Research and presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting, one of the world’s most respected scientific forums.
The abstract, titled “REPYR-SC1 Hemp Extract Exhibits Potent Inhibition of Squamous Cell Carcinoma”, highlighted the compound’s research-level significance and its potential relevance in understanding damaged and irregular skin cell behavior.
REPYR-SC1™ In Action — Charting the Evidence
48-Hour Laboratory Observations
In controlled laboratory settings within a university-affiliated academic research environment, REPYR-SC1™ was evaluated using human basal cell research models over a 48-hour period.
The compound demonstrated a clear, concentration-dependent effect on cellular activity, with lower viability observed as exposure levels increased. Notably, measurable biological response was observed even at lower concentrations.
The chart above illustrates this dose-responsive trend, highlighting why REPYR-SC1™ has continued to attract scientific interest and further academic evaluation.
These observations were made in laboratory research models. Physicians Grade products are intended for cosmetic and wellness use only.Within 48 hours, REPYR-SC1™ reduced Basal Cell Carcinoma cell counts by over 95% in a concentration-dependent manner.
REPYR-SC1™ vs Metastatic Melanoma Kill Curve (up to 36h)
REPYR-SC1™ achieved 100% melanoma cell death by 36 hours at 10 µL/mL and 80% reduction at 5 µL/mL.
REPYR-SC1™ and Skin Cell Research Models — 36–48 Hour Observations
REPYR-SC1™ was evaluated in controlled laboratory settings within a university-affiliated academic research environment using human skin cell research models over a 36–48 hour period.
Across multiple concentrations, the compound demonstrated a clear, time- and dose-dependent effect on cellular activity, with progressively lower viability observed as exposure increased. Notably, higher concentrations produced more rapid changes within the observed timeframe.
The chart above illustrates this consistent dose-responsive trend, which contributed to continued scientific interest and further academic evaluation of REPYR-SC1™.
Laboratory observations shown are based on controlled research models. Physicians Grade products are intended for cosmetic and wellness use only.REPYR-SC1™ achieved 100% cancer cell death at 5 µL/mL within 36 hours and approximately 95% at 1 µL/mL within 48 hours.
REPYR-SC1™ and Squamous Cell Research Models (SCC-15) — 36–72 Hour Observations
REPYR-SC1™ was evaluated in controlled laboratory settings within a university-affiliated academic research environment using human squamous cell research models over a 36–72 hour period.
Across multiple concentrations, the compound demonstrated a clear time- and dose-dependent effect on cellular activity, with higher concentrations producing more rapid changes and lower concentrations showing progressive response over time.
The chart above illustrates this consistent, concentration-dependent trend, supporting continued scientific interest in REPYR-SC1™ within academic research settings focused on skin biology.
Laboratory observations shown are based on controlled research models. Physicians Grade products are intended for cosmetic and wellness use only.Controlled laboratory data demonstrated a consistent, concentration-dependent trend in SCC-15 research models over time.”
From Research to Responsible Formulation
Physicians Grade does not position REPYR-SC1™ as a medical treatment. Instead, we apply academic-level rigor to product development, formulation consistency, and ingredient transparency.
Unlike conventional skincare products developed in isolation, REPYR-SC1™ emerged from institutional research environments where compounds are evaluated for biological relevance, safety, and repeatability long before reaching consumers.
This foundation allows us to create products that support the skin’s natural processes without overstating claims or compromising integrity.
The Future of Medical-Grade Skincare
At Physicians Grade, our vision is simple: to deliver skincare that’s more than cosmetic — it’s clinical, proven, and personal. By combining medical research with botanical precision, we’ve created a line that doesn’t just treat the surface but helps the skin recover where it matters most.
Crafted for Care, Trusted for Results
We specialize in crafting premium CBD and wellness products designed for superior quality and efficacy.
Safe & Effective
Years making products
Satisfaction Guarantee
Happy Customers
Sign Up for Our Newsletter
Get 25% off + free shipping when you sign up with your email.
Latest News
Follow Us on Instagram
Follow us on Instagram to see how our community uses Physicians Grade for everyday wellness.
